Cord Blood Stem Cells Information

describe how a pluripotent stem cell becomes a leucocyte?

Public Comments

1. First, the stem cell shaves itself from head to tail, then paints itself a rather fetching shade of lilac. After a vigorous run and an ancient initiation ceremony, the leucocyte leaders either vote him into the fold, or reject his application.
2. Hematopoietic stem cells (HSC) are stem cells found in the bone marrow. HSC are the precursor cells which give rise to all the types of both the myeloid and lymphoid lineages. This includes monocytes and macrophages, neutrophils, basophils, eosinophils, T-cells, B-cells, NK-cells, microglia, erythrocytes (red blood cells), megakaryocytes (e.g. platelets), and dendritic cells. As stem cells, they are defined by their ability to form multiple cell types (pluripotency) and their ability to self-renew. Individual HSC have the ability to give rise to any of the end-stage blood cell types. During differentiation, daughter cells derived from HSC undertake a series of commitment decisions, retaining differentiation potential for some lineages while losing others. Intermediate cells become progressively more restricted in their lineage potential, until eventually lineage-committed end stage cells are generated. Leukocytes include lymphocytes, moncytes, neutrophils, basophils and eosinophils. The sequence of differentiation for leukocytes is: 1. Stem cell (hemocytoblast) > Myeloblast > Progranulocyte > then either basophil, Eosinophil, or Neutrophil 2. Stem cell (hemocytoblast) > Lymphoblast > Lymphocyte 3. Stem cell (hemocytoblast) > Monoblast > Monocyte